Biochemical Properties of the Transformation of Unchanged and Oxidized Forms of Decis into the Blood

Abstract

Experiments have established the role of albumin and globulin fractions of blood serum and supernatant in the connecting, transport, transferring and elimination of unchanged and oxidized forms of Decis. It was found that the biochemical processes of transformation are related to the active movement of protein fractions (albumin, globulins) directly from the separating surface of erythrocytoplasm into the blood serum (tropism function of erythrocytes), Or as a result of a change in the binding force of the oxidized form of the drug (disruption of electrostatic processes), it migrates directly from the surface of the erythrocyte into the serum. These physicochemical processes play an important role in the dislocation of the Decis (serum, supernatant), which is related to the mechanisms, the essence of which is to maintain a constant level of active drug at the expense of depot processes that take place - erythrocyte-plasma-splitting surface.